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Will Cassava Sciences announce a new Alzheimer's drug candidate by the end of 2025?
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Cassava's Simufilam Fails Phase 3 Alzheimer's Trial; Company Discontinues Trials, Shares Plunge 85%
Nov 25, 2024, 12:55 PM
Cassava Sciences announced that its Alzheimer's drug, Simufilam, failed to meet co-primary, secondary, and exploratory endpoints in the Phase 3 ReThink-ALZ trial. The study showed that Simufilam did not demonstrate a significant reduction in cognitive or functional decline versus placebo in patients with mild-to-moderate Alzheimer's disease. Despite Simufilam demonstrating an overall favorable safety profile, the company plans to discontinue the second Phase 3 ReFocus-ALZ trial and the Open Label Extension study. Following the announcement, trading of Cassava Sciences' stock was halted, and the stock price dropped by over 85% pre-market. The company plans to present detailed results at a future medical meeting.
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New Alzheimer's drug candidate announced • 25%
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