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Will Anti-IL-11 drug reduce cancer incidence in human trials by end of 2025?
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Resolution / Starting Odds
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Results published in peer-reviewed medical journals or clinical trial outcomes
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Study Shows Anti-IL-11 Drug Extends Lifespan of Mice by 25%, Reduces Cancer and Gray Hair
Jul 17, 2024, 04:25 PM
A recent study published in Nature has shown that inhibiting interleukin-11 (IL-11), a pro-inflammatory cytokine, can significantly extend the lifespan of mice. The research demonstrated that both genetic deletion and pharmacological inhibition of IL-11 increased the lifespan of laboratory mice by nearly 25%. The treated mice, referred to as 'supermodel grannies' due to their youthful appearance, were healthier, stronger, and exhibited fewer age-related health problems. The study found that male mice experienced a 22.5% increase in median lifespan. Additionally, the treatment reduced the incidence of cancer and gray hair. Anti-IL-11 therapies are already in human clinical trials, raising hopes for their potential application in extending human lifespan and improving healthspan.
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