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Will VK2735 Phase 2 study report moderate/severe nausea?
2
Resolution / Starting Odds
Yes • 50%
No • 50%
Clinical trial results or official press releases from Viking Therapeutics
Story
Viking's VK2735 Shows 8.2% Weight Loss with Placebo-Like Safety at ObesityWeek 2024
Nov 4, 2024, 10:57 AM
Viking Therapeutics reported positive early-stage clinical trial data for its oral obesity drug VK2735 at the ObesityWeek 2024 conference, exceeding expectations. The drug demonstrated a weight loss of up to 8.2% from baseline (6.8% placebo-adjusted) after 28 days of dosing with the 100 mg daily dose. VK2735 was well-tolerated, showing a safety profile similar to placebo, with no moderate or severe nausea reported even at the highest doses. Patients maintained weight loss long after the last dose. The company plans to initiate a Phase 2 study of the oral tablet formulation by the end of the year and discuss the clinical path forward with the FDA for the injectable formulation later in the quarter.
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Exceeds expectations • 25%
Meets expectations • 25%
Below expectations • 25%
Study discontinued • 25%
All endpoints met • 33%
Some endpoints met • 33%
No endpoints met • 33%
Positive efficacy and safety • 25%
Positive efficacy, negative safety • 25%
Negative efficacy • 25%
Inconclusive • 25%
Highly effective • 25%
Moderately effective • 25%
Slightly effective • 25%
Ineffective • 25%
Nausea • 25%
Fatigue • 25%
Diarrhea • 25%
Other • 25%
Dry mouth • 25%
Drowsiness • 25%
Nausea • 25%
Other • 25%
Less than 5 patients • 33%
5 to 9 patients • 34%
10 or more patients • 33%
