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Will Sage Therapeutics initiate a new clinical trial for any drug by end of 2024?
2
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Clinical trial registries and company announcements
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Sage and Biogen's SAGE-324 Fails in Mid-Stage Study for Essential Tremor, Stock Drops 25%
Jul 24, 2024, 12:11 PM
Sage Therapeutics and Biogen have announced the topline results from their Phase 2 KINETIC 2 study of SAGE-324 for the treatment of essential tremor. The mid-stage trial did not demonstrate statistically significant differences between any dose of SAGE-324 and placebo in the change from baseline for the primary endpoint. As a result, Biogen and Sage do not plan to conduct further studies for this neurological disorder drug. This failure marks another setback for Biogen's $3 billion alliance with Sage Therapeutics. The experimental pill failed to quell involuntary muscle shaking in patients with essential tremor. Following the announcement, Sage Therapeutics' stock dropped by 25%.
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