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Kalihinol Analog MED6-189 Shows Promise Against Drug-Resistant Malaria Parasite

Sep 27, 2024, 07:28 AM

A synthetic compound, MED6-189, a kalihinol analog, has shown promise against both drug-sensitive and drug-resistant strains of the malaria parasite Plasmodium falciparum. The compound disrupts apicoplast function and vesicular trafficking in the parasite, effectively killing it. This discovery, highlighted in a study published in Science, demonstrated efficacy in a humanized mouse model of malaria. Research by @UCRiverside and @ScienceMagazine indicates that MED6-189 could be a significant advancement in the fight against malaria.