University of Iceland Study Links Rare Genotype in 10,000 Women to 9 Years Earlier Menopause via CCDC201 Gene

Aug 28, 2024, 04:09 AM

Research led by the University of Iceland and deCODE genetics has identified a rare genotype in approximately 10,000 women of Northern European descent that is linked to an earlier onset of menopause, occurring nine years earlier than the average age. The study highlights the homozygosity of a loss of function variant (p.Arg162Ter) in the CCDC201 gene, which has only recently been included in the human gene database. This discovery sheds light on the genetic factors contributing to early menopause, emphasizing the significant role genetics play in this biological process.