Nature Study by Petter Brodin Finds Testosterone Therapy Alters Immune System in Trans Men

Sep 4, 2024, 03:24 PM

Recent research published in Nature reveals that gender-affirming testosterone therapy in trans men results in significant changes to their immune systems, making them more similar to cisgender men. The study, led by Petter Brodin and colleagues, highlights that testosterone therapy reduces type I interferon and enhances TNF signatures. This research provides insights into why males are more vulnerable to severe infections, such as acute COVID-19, while females are more prone to autoimmune diseases like SLE and MS. The findings, published in Nature, could help scientists better understand sex differences in immune responses among both cisgender and transgender individuals.