'Deadpool & Wolverine' is projected to have a record-breaking opening at the box office, with estimates ranging between $200 million and $239 million for its domestic debut. This would surpass the current highest opening for an R-rated movie, which is held by 'Deadpool' at $132 million. The film is generating significant consumer excitement, topping the list of anticipated titles. The highest R-rated opening of all time is expected.