Arc Institute's Bridge RNA-Guided DNA Recombination Published in Nature for Precise Genome Editing

Jun 26, 2024, 04:20 PM

Researchers from the Arc Institute have introduced a groundbreaking genome engineering technology known as bridge RNA-guided DNA recombination. This new mechanism, detailed in two papers published in Nature, allows for the programmable insertion, excision, or inversion of DNA sequences. Unlike CRISPR, bridge RNA-guided DNA recombination does not rely on cellular repair mechanisms, potentially making it safer and more precise. The discovery includes three atomic structures of the first natural RNA-guided recombinase, which enhances the power and precision of genome editing for long DNA sequences. This modular system involves the IS110 recombinase and non-coding RNA, significantly reshaping animal and plant genomes.