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Percentage of MASH resolution in final ESSENCE trial results
2
Resolution / Starting Odds
Less than 60% • 25%
60% to 65% • 25%
65% to 70% • 25%
More than 70% • 25%
Published ESSENCE trial results
Story
Novo Nordisk's Semaglutide Shows Promise in 72-Week Phase 3 Liver Disease Trial with MASH Resolution
Nov 1, 2024, 12:17 PM
Novo Nordisk's semaglutide 2.4 mg has demonstrated significant improvements in liver fibrosis and MASH resolution in its phase 3 ESSENCE trial. The trial, which included 1,200 adults, showed that after 72 weeks, 37% of patients treated with semaglutide experienced fibrosis improvement compared to 22.5% on placebo. Additionally, 62.9% of patients achieved MASH resolution, compared to 34.1% on placebo. The drug also showed a positive safety profile. Novo Nordisk plans to file for regulatory approvals in the US and EU in the first half of 2025. Detailed results from the ESSENCE trial will be presented at an upcoming scientific conference.
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Less than 60% • 25%
60% to 70% • 25%
70% to 80% • 25%
More than 80% • 25%
Less than 25% • 25%
25% to 30% • 25%
30% to 35% • 25%
More than 35% • 25%
Less than 50% • 25%
50% - 60% • 25%
60% - 70% • 25%
More than 70% • 25%
0-10 patients • 25%
11-20 patients • 25%
21-30 patients • 25%
More than 30 patients • 25%
AE rate < 20% • 25%
AE rate 20-30% • 25%
AE rate 30-40% • 25%
AE rate > 40% • 25%