Scientific journals or major health news outlets

APOE4 Gene Variant Linked to 100% Chance of Alzheimer's, Study Finds

May 6, 2024, 06:45 PM

Recent studies have identified a distinct genetic form of Alzheimer's disease linked to the APOE4 gene variant. Researchers have found that individuals with two copies of the APOE4 gene, known as homozygotes, exhibit nearly a 100% chance of developing Alzheimer's and show significant biological markers such as abnormal amyloid levels and biomarkers in cerebrospinal fluid. This discovery marks a significant shift in understanding the gene's role from a risk factor to a direct cause, potentially leading to earlier diagnoses and more targeted treatments.