Reports from health organizations or research institutions

Gates-Funded Mosquitoes Deliver Malaria Vaccines with 89% Success, Raising Ethical Concerns

Jan 2, 2025, 03:43 PM

Researchers at the Leiden University Medical Center in the Netherlands, funded by the Bill & Melinda Gates Foundation with $1.57 million, have developed genetically modified mosquitoes capable of delivering malaria vaccines through their bites. This method, referred to as 'flying vaccinators,' was tested in clinical trials involving 43 participants and showed promising results, with 89% of those bitten by GA2-modified mosquitoes developing immunity. The genetically modified parasites used in the trials were designed to infect humans without causing illness, allowing the immune system to build resistance. While the approach has demonstrated potential in controlled settings, researchers acknowledge significant challenges in scaling it for widespread use, citing ethical concerns, logistical barriers, and the need for informed consent. The study, published in the New England Journal of Medicine, highlights the innovative use of mosquito behavior to combat malaria but raises debates over the implications of using such methods on a larger scale.